Holoxan Uromitexan comb pack injection is used in the treatment of cancer. Holoxan Uromitexan comb pack injection is a combination of two medicines: Mesna and Ifosfamide. Mesna is an anti-cancer medication. It works by damaging the genetic material (DNA) of the cancer cells and stops their growth and multiplication. Ifosfamide is a cytoprotective medicine which is added to reduce the risk of bleeding and swelling in the bladder caused by Mesna.